文章基本信息

标题：EFFECT OF PREGNANCY ON CADMIUM-TREATED RATS
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作者：Yukio TAKIZAWA ; Isao NAKAMURA ; Reiko KURAYAMA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1981
卷号：19
期号：3
页码：171-176
DOI：10.2486/indhealth.19.171
出版社：National Institute of Occupational Safety and Health
摘要：It it well known that itai-itai disease with the osteopathy is broken out among multiparas, 40 years of age and up Japanese residents. In this paper we described an experimental study of effect of pregnancy on cadmium treated rats. Female mature rats were administered drinking water containing 50 and 200 ppm cadmium as CdCl₂. During 180 days of the experiment, three times of pregnancy were succesful, though slight depression of body weight gain was noticed in the 200 ppm group. The cadmium was accumulated in the kidneys, liver and bone proportionally to the amount of cadmium administered. No significant change was recognized in serum calcium, phosphorus and alkaline phosphatase levels after 180 days. Though cadmium 200 ppm treated rats showed slight histological lesions in the proximal convoluted tubles of the kidney, there appeared to be no osteo-malacia including excess formation of osteoid tissue.
关键词：Cadmium poisoning;Pregnancy;Heavy metal;Histopathology;Rat