文章基本信息

标题：DEALKYLATION OF TETRAALKYLTIN COMPOUNDS IN THE INTESTINAL MUCOSA OF RABBITS
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作者：Hideaki IWAI ; Osamu WADA
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1981
卷号：19
期号：4
页码：247-253
DOI：10.2486/indhealth.19.247
出版社：National Institute of Occupational Safety and Health
摘要：Dealkylation of tetraalkyltin compounds (alkyl: ethyl or butyl) in the intestinal mucosa and in the intestinal contents of the rabbits was investigated in situ and in vitro. Tetraethyl and tetrabutyltin compounds were directly infused into the small intestine isolated in vivo by two forceps after making biliary fistula. Amounts of tetraalkyltin compounds and dealkylated compounds, trialkyltin, in portal vein blood, venous blood, bile, and organs were measured as a function of time after the injection. In the earliest stage, the concentrations of dealkylated compounds in portal vein blood were higher than that in systemic venous blood. This result, together with the finding that no conversion occurs in intestinal contents in vitro, suggests that the conversion of tetraalkyltin compounds into trialkyltin compounds takes place in intestinal mucosa before tetraalkyltin compounds are taken into the liver.
关键词：Dealkylation;Tetraalkyltin;Trialkyltin;Organotin;Intestinal mucosa