文章基本信息

标题：Studies on the Inhibition of Erythrocyte and Hepatic Delta-Aminolevulinic Acid Dehydratase Activities and its Restoration in Mice Exposed to Lead
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作者：Naomi KOGA ; Yukio HIRAI ; Tohru HASEGAWA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1984
卷号：22
期号：2
页码：83-90
DOI：10.2486/indhealth.22.83
出版社：National Institute of Occupational Safety and Health
摘要：The comparative study on lead-induced inhibition of delta-aminolevulinic acid dehydratase (ALA-D) activity in both blood and liver and that on its restoration were performed using the mice which were given ad libitum a lead containing water (500 ppm as lead) for 30 days. The ALA-D inhibition in the liver was very mild compared with that in the blood, in spite of high accumulation of lead into the liver. The depressed ALA-D activity in both blood and liver was rapidly restored by means of the cessation of lead exposure. The gel filtration chromatography showed that the chromatographic ellution pattern of zinc from the supernatant of the liver homogenate corresponds well to that of protein-like substances of the supernatant. However, the lead-binding protein in the liver was not detected in mice exposed to lead for 30 days.
关键词：Lead-exposed mice;Erythrocyte ALA-D;Liver ALA-D;Inhibition and restoration;Liver zinc;Gel filtration chromatography