文章基本信息

标题：Exacerbation of Nickel Induced Oxidative Response by Vitamin E
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作者：Mirza M. HUSAIN ; Nihal AHMAD ; Sanjay GUPTA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1995
卷号：33
期号：3
页码：143-152
DOI：10.2486/indhealth.33.143
出版社：National Institute of Occupational Safety and Health
摘要：Vitamin E (α-tocopherol), a well known naturally occurring chain breaking antioxidant and a free radical scavenger was found to exacerbate nickel (Ni) toxicity in mice. Vitamin E (Vit. E) mediated enhancement of nickel toxicity was demonstrated by (i) enhanced mortality in mice treated with Ni and Vit. E (ii) increased hepatic lipid peroxidation, (iii) increased rate of benzoate hydroxylation, and (iv) liposomal membrane damage.
关键词：Vitamin E;Ni toxicity;Reactive oxygen species;Benzoate hydroxylation;Liposomal membrane damage