文章基本信息

标题：Renal Dysfunction Indicators in Lead Exposed Workers
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作者：Kap-Yeol JUNG ; Sang-Ju LEE ; Joon-Youn KIM 等
期刊名称：Journal of Occupational Health
印刷版ISSN：1341-9145
电子版ISSN：1348-9585
出版年度：1998
卷号：40
期号：2
页码：103-109
DOI：10.1539/joh.40.103
出版社：Japan Society for Occupational Health
摘要：Real Dysfunction Indicators in Lead Exposed Workers: Kap-Yeol JUNG, et al. Department of Preventive Medicine and Industrial Medicine Research Institute, Dong-A University School of Medicine —This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction related to lead exposure. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the “exposed” group) and 64 male office workers (the “control” group). Blood lead, blood zinc protoporphyrin, urine lead, urine coproporphyrin, δ-aminolevulinic acid dehydratase activity, and urine δ-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen, serum creatinine, serum uric acid, urine N-acetyl-β-D-lucosaminidase, urine albumin, urine α₁-microglobulin and urine β₂-microglobulin were used as indicators of renal dysfunction. The urine α₁-microglobulin level was significantly associated with the lead exposure level. Blood urea nitrogen, urine N-acetyl-β-D-glucosaminidase and urine al-microglobulin levels were highly correlated with indicators of lead exposure. Urine α₁-microglobulin had the highest correlation with other indicators of renal function. Conclusively, blood urea nitrogen, urine N-acetyl-β-D-glucosaminidase and urine α₁-microglobulin are useful indicators, but urine α₁-microglobulin is the earliest and the most valuable indicator of renal dysfunction due to lead exposure.
关键词：Renal function indicators;Lead exposure