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标题：Acute and Repeated Inhalation Toxicity of 1-Bromopropane in SD Rats
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作者：Hyeon-Yeong KIM ; Yong-Hyun CHUNG ; Jae-Hwang JEONG 等
期刊名称：Journal of Occupational Health
印刷版ISSN：1341-9145
电子版ISSN：1348-9585
出版年度：1999
卷号：41
期号：2
页码：121-128
DOI：10.1539/joh.41.121
出版社：Japan Society for Occupational Health
摘要：Acute and Repeated Inhalation Toxicity of 1-Bromopropane in SD Rats: Hyeon-Yeong KIM et al. Industrial Chemicals Research Center, Industrial Health Research Institute, Korea —The acute and repeated inhalation toxicity of 1-bromopropane (1-BP) in SD rats were investigated. LC₅₀ for four-hour exposure was 14, 374 ppm (95% confidence limit: 13, 624-15, 596 ppm). It was revealed to be irritating to the eyes with lacrimation in all four-hour exposure rats. No other abnormal clinical signs and gross findings related to the 1-BP exposure were observed. An experiment on repeated exposure to 0, 50, 300, and 1, 800 ppm for six hrs/day, five days/week, for eight weeks was conducted. A decrease in body weights and increase in relative liver weight in both male and female rats were observed in the 1, 800 ppm exposure group (p<0.001 vs. control group). No other significant changes in feed consumption, urinanalysis, hematology and serum biochemistry were observed. Histopathological examinations did not reveal any 1-BP-related changes.
关键词：1-Bromopropane;Inhalation Toxicity;LC50