文章基本信息

标题：EFFECT OF VITAMIN B6 DEFICIENCY ON COLLAGEN METABOLISM IN RATS
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作者：Naoyoshi TANE ; Tomohiko TAKEDA ; Taneaki SHIOJI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1976
卷号：22
期号：2
页码：105-114
DOI：10.3177/jnsv.22.105
出版社：Center for Academic Publications Japan
摘要：The effects of VB₆ deficiency on collagen metabolism were studied using young and adult rats. It was observed in VB₆ deficient rats, that both the amount of urinary hydroxyproline and salt soluble fraction of skin collagen decreased. Furthermore, decrease of the α-component and increase of the β-com ponent were also found in the soluble collagen. However, the activity of plasma amine oxidase was lower and the aldehyde content in the acid soluble collagen was also lower than the control group. These changes were revealed more clearly in young growing rats than in adult rats. Based on these results, it may be that VB₆ participates in the allysine (α-amino-adipic-δ-semialdehyde) formation which is considered as the first step of collagen maturation and also in the synthesis of protocollagen peptide chains.