文章基本信息

标题：INHIBITORY EFFECT OF CADMIUM ON VITAMIN D STIMULATED CALCIUM TRANSPORT IN RAT DUODENUM IN VITRO
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作者：Fukiko TSURUKI ; Yoko OTAWARA ; Houi Ling WUNG 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1978
卷号：24
期号：3
页码：237-242
DOI：10.3177/jnsv.24.237
出版社：Center for Academic Publications Japan
摘要：In vitro effect of cadmium on vitamin D-stimulated calcium transport in the rat was studied using the everted gut sac technique. Calcium transport was significantly inhibited by the addition of cadmium to the mucosal incubation medium. Furthermore, the kinetic analysis of in hibitory effect of cadmium on calcium transport revealed that the type of inhibition was competitive. The apparent “ Km ” and “ V _max” value for calcium was 1.0 mM, and 2.86 μmoles ml^-1 ⋅hr^-1, respectively. An apparent “ K_i ” for cadmium was 0.02mM