文章基本信息

标题：THE EFFECT OF VITAMIN D3 AND DIETARY CALCIUM LEVEL ON THE CADMIUM-INDUCED MORPHOLOGICAL AND BIOCHEMICAL CHANGES IN RAT INTESTINAL MUCOSA
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作者：Setsuko NODA ; Kura KUBOTA ; Kazuhiko YAMADA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1978
卷号：24
期号：4
页码：405-418
DOI：10.3177/jnsv.24.405
出版社：Center for Academic Publications Japan
摘要：The effect of vitamin D₃ and dietary calcium level on the cadmium-induced changes was observed in the duodena of rats raised on various diets differing in vitamin D and calcium levels. Observation with scanning electron microscopy revealed that vitamin D and dietary calcium were required for normal intestinal villi and microvilli formation. The damaged cells were observed in the intestinall villi of cadmium-exposed rats. The length of microvilli was shortened in the cadmium-exposed rats. Furthermore, dietary cadmium reduced the enzyme activities in microvilli. Especially, alkaline phosphatase activity was reduced in the cadmium-exposed groups, even though it was still responsive to vitamin D₃. These effects with cadmium were modulated by vitamin D₃ and dietary calcium level. That is, in the presence of vitamin D3 and calcium, the effect of cadmium on intestinal villi and microvilli was reduced.