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标题：Enhancing Effect of Carrageenan on the Induction of Rat Colonic Tumors by 1, 2-Dimethylhydrazine and Its Relation to β-Glucuronidase Activities in Feces and Other Tissues
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作者：Shoichi ARAKAWA ; Masanao OKUMURA ; Seiji YAMADA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1986
卷号：32
期号：5
页码：481-485
DOI：10.3177/jnsv.32.481
出版社：Center for Academic Publications Japan
摘要：Since it has been demonstrated that a high level of fat is a dietary factor in the etiology of colon cancer, the effect of carrageenan, a polysaccharide extracted from the red seaweeds, on 1, 2-dimethylhydra-zine-induced colonic tumors in rats fed a semipurified control diet containing an ordinary level of fat was studied. Nevertheless, the enhancing effect of carrageenan on colonic tumors was observed. The rats fed a carrageenan diet had approximately twice the fecal weight compared to the rats fed a control diet. While no significant differences were found in β-glucuronidase activities in colonic mucosa, liver or plasma in the car-rageenan-fed rats and controls, the activity in feces was significantly lower in the carrageenan-fed rats. At least, no β-glucuronidase activity seemed to be related to the tumor-enhancing effect of carrageenan.
关键词：colonic tumor;1,2-dimethylhydrazine;carrageenan;β-glucuronidase