文章基本信息

标题：Effects of Dietary Methionine, Cystine, and Glycine on Endogenous Hypercholesterolemia in Hepatoma-Bearing Rats
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作者：Kazumi YAGASAKI ; Michie MACHIDA ; Ryuhei FUNABIKI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1986
卷号：32
期号：6
页码：643-651
DOI：10.3177/jnsv.32.643
出版社：Center for Academic Publications Japan
摘要：The effects on hypercholesterolemia of dietary additions of cystine (Cys), methionine (Met), glycine (Gly), and a combination of Met and Gly to a 20% casein diet were studied in male Donryu rats subcutaneously implanted with an ascites hepatoma line of AH109A cells. The hepatoma-bearing rats fed the 20% casein diet lapsed into both endogenous hypertriglyceridemia and hypercholesterolemia when compared to hepatoma-free (normal) rats fed the same diet. The hypercholesterolemia was due to an elevation (3.2 fold) in the very low-density lipoprotein plus low-density lipoprotein (VLDL+LDL)-cholesterol (Ch) level. The high-density lipoprotein (HDL)-Ch level was slightly but significantly decreased. These lipoprotein changes in hepatoma-bearing rats resulted in a marked (4.5 fold) increase in the atherogenic index (AI, (VLDL+LDL)-Ch/HDL-Ch) in comparison with that of tumor-free rats. The dietary additions of l.2% Met, l.2% Cys, and a combination of 1.2% Met and 2.5% Gly significantly suppressed the hepatoma-induced increase in (VLDL+LDL)-Ch with no influence on the hepatoma-induced decrease in HDL-Ch, leading to a noticeable fall in AT. These results indicate that hepatoma-bearing rats are useful as an endogenously hyperlipidemic model and that some dietary amino acids are capable of improving hepatoma-induced hypercholesterolemia and abnormal serum lipoprotein profiles.
关键词：hypercholesterolemia;hypertriglyceridemia;hepatoma;methionine;cystine;glycine;serum cholesterol;lipoprotein