文章基本信息

标题：Mitigation of Obesity by BRL 2b830A, a New β-Adreno-ceptor Agonist, in MSG Obese Mice
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作者：Toshihide YOSHIDA ; Keiji YOSHIOKA ; Kohkichi KAMANARU 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1990
卷号：36
期号：1
页码：75-80
DOI：10.3177/jnsv.36.75
出版社：Center for Academic Publications Japan
摘要：Half of the mice in both the monosodium-L-glutamate (MSG)-induced obesity and saline control groups were given BRL 26830A via a gastric tube at a daily dose of 5mg/kg for 2 weeks, and the other half given distilled water. BRL 26830A administration significantly increased guanosine-5'-diphosphate (GDP)-binding in brown adipose tissue (BAT) and the resting metabolic rate (RMR), and significantly reduced re-troperitoneal white adipose tissue (WAT) pads in both groups. It also markedly reduced body weight in MSG obese mice that had reduced BAT thermogenesis and decreased RMR. However, food intake was unchanged in both groups. Neither β₁- nor β₂-selective antagonists affected the increase of RMR induced by BRL 26830A, but a non-selective β-antagonist completely inhibited its increase. These results suggest that BRL 26830A, which is a new β-adrenoceptorr agonist, stimulates BAT thermogenesis, increases RMR, and reduces WAT, thus contributing to the mitigation of obesity.
关键词：β-adrenoceptor agonist (BRL 26830A);anti-obesity effect;brown adipose tissue (BAT);GDP-binding;resting metabolic rate (RMP);MSG obese mice;β1-selective antagonist;β2-selective antagonist