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标题：Cardiotoxicity in Magnesium-Deficient Rats Fed Cadmium
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作者：Shoji NISHIYAMA ; Noboru SAITO ; Yuuko KONISHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1990
卷号：36
期号：1
页码：33-44
DOI：10.3177/jnsv.36.33
出版社：Center for Academic Publications Japan
摘要：We studied the cardiotoxicity in magnesium (Mg)-deficient male rats fed 50μg/g Cd for 45 consecutive days. Cd at a low con-centration (0.28ppm) in the heart induced cardiotoxic effects manifested by a decrease of the heart rate and weight and histopathological changes in the presence of Mg deficiency though Cd supplementation to a normal diet did not induce any cardiotoxic effect. Cardiac output (CO) did not increase in response to the decrease in the total peripheral resistance (TPR) in the Mg-deficient rats fed Cd, suggesting that supplementation of Cd to the Mg-deficient diet may lead to a decrease in the myocardial contractile function. However, supplementation of Cd to Mg-deficient diet also alleviated myocardial necrosis and Ca overload observed in the heart of Mg-deficient rats. The present data suggest that Cd ameliorates Ca overload in the heart of Mg-deficient rats but also may inhibit the release of Ca²⁺, which is a major determinant of the level of contractile force.
关键词：cardiotoxicity;magnesium deficiency;cadmium;rats