文章基本信息

标题：Effect of Nicotine on Norepinephrine Turnover and Thermogenesis in Brown Adipose Tissue and Metabolic Rate in MSG Obese Mice
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作者：Toshihide YOSHIDA ; Keiji YOSHIOKA ; Noriya HIRAOKA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1990
卷号：36
期号：2
页码：123-130
DOI：10.3177/jnsv.36.123
出版社：Center for Academic Publications Japan
摘要：To clarify whether nicotine stimulates the sympathetic nervous system (SNS) and thermogenesis in brown adipose tissue (BAT) and whether it promotes the resting metabolic rate (RMR), with resulting mitigation of obesity, we measured norepinephrine (NE) turnover (an indicator of SNS activity), guanosine-5'-diphosphate (GDP) binding (a thermogenic indicator), oxygen consumption in BAT, and RMR in monosodium-L-glutamate (MSG) obese and saline control mice after 2 weeks treatment with nicotine. Nicotine significantly increased NE turnover, GDP binding, oxygen consumption in BAT, and RMR, and significantly reduced body weight in MSG obese mice as well as in control mice without affecting food intake. These results suggest that nicotine stimulates NE turnover and thermogenesis in BAT, and promotes RMR, all of which contribute to the mitigation of obesity.
关键词：nicotine;norepinephrine turnover;thermogenesis;GDP binding;oxygen consumption;RMR;brown adipose tissue;MSG obese mice