文章基本信息

标题：Alteration of β-D-Glucan from Edible Mushroom after Injection into Mouse Peritoneal Cavity
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作者：Yoshiaki SONE ; Satoaki SHIBATA ; Etsu KISHIDA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1994
卷号：40
期号：4
页码：335-341
DOI：10.3177/jnsv.40.335
出版社：Center for Academic Publications Japan
摘要：Tritium-labeled antitumor β-D-glucan derivative (T-labeled glucan) was prepared from the branched β-1, 3-D-glucan of an edible mushroom, Volvariella volvacea , by its periodate oxidation followed by reduction with NaBT₄. Twenty-three hours after T-labeled glucan had been injected into the mouse peritoneal cavity, about 3% of the total radioactivity injected was found in the mouse serum. In spite of the fact that T-labeled glucan had no affinity to the anion-exchange column before injection, about 50% of the labeled β-D-glucan in the serum thus obtained was adsorbed onto the column. The labeled β-D-glucan fraction eluted from the column by salt gradient showed antitumor activity in vivo .
关键词：edible mushroom β-D-glucan;labeled β-D-glucan;antitumor activity;intraperitoneal injection