文章基本信息

标题：Effect of Cysteine on Expression of Cystathionine β-Synthase in the Rat Liver
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作者：Nobuko YAMAMOTO ; Takehiko TANAKA ; Tamio NOGUCHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1995
卷号：41
期号：2
页码：197-205
DOI：10.3177/jnsv.41.197
出版社：Center for Academic Publications Japan
摘要：Hepatic cystathionine β-synthase activity is decreased by the addition of cysteine to the diet. This effect of cysteine was slightly greater in diets containing 0.25% methionine than in those containing 1 % methionine, and was reduced during aging. Similar changes were ob-served in the level of the mRNA of this enzyme, although the changes in the trancscript levels were slightly greater than the changes in enzyme activity. Thus, we conclude that the addition of cysteine to a methionine-containing diet causes a decrease in cystathionine Q-synthase activity mainly by diminishing its mRNA level.
关键词：cystathionine β-synthase;methionine-sparing effect of cyste-ine;gene expression;rat liver