文章基本信息

标题：Effect of L-Ascorbic Acid on the Oxidative Modification of Apolipoprotein E in Human Very-Low-Density Lipoprotein
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作者：Hirofumi ARAI ; Kazuyuki NAKAMURA
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2004
卷号：50
期号：1
页码：66-68
DOI：10.3177/jnsv.50.66
出版社：Center for Academic Publications Japan
摘要：Antioxidant activity of L-ascorbic acid (AsA) against oxidative modification of apolipoprotein (apo) E in human very-low-density lipoprotein (VLDL) Was investigated. The VLDL oxidation induced by peroxyl radicals and peroxynitrite led to lipid peroxidation and oxidative modification of apoE. The binding activity of apoE to heparin was decreased by the oxidative modification. AsA (200, 500, and 1, 000μM) inhibited both the lipid peroxidation and the oxidative modification of apoE. These results suggest that AsA prevents the biologi-cal function of apoE in VLDL from the oxidation by free radicals.