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标题：Short-Term Ascorbic Acid Deficiency Does Not Impair Antioxidant Status in Lens of Guinea Pigs
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作者：Yoshiji OHTA ; Takafumi NIWA ; Takashi YAMASAKI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2004
卷号：50
期号：2
页码：149-153
DOI：10.3177/jnsv.50.149
出版社：Center for Academic Publications Japan
摘要：We examined whether short-term ascorbic acid deficiency impairs antioxidant status in the lens of guinea pigs. Male guinea pigs aged 4 wk were given a scorbutic diet (20g/animal per day) with and without ascorbic acid (400mg/animal per day) in drinking water for 3 wk. The ascorbic acid-deficient group showed no lens opacity. The ascorbic aciddeficient group had 14% of serum ascorbic acid concentration, 6% of aqueous humor ascorbic acid concentration, and 18% of lens ascorbic acid content in the ascorbic acid-adequate group. There were no differences in the contents of lens reduced glutathione and thiobarbituric acid reactive substances, an index of lipid peroxidation, between the ascorbic acid-deficient and adequate groups, while the deficient group had higher lens vitamin E content than the adequate group. The ascorbic acid-deficient group had higher serum vitamin E concentration than the ascorbic acid adequate group, while there were no differences in the concentrations of serum reduced glutathione and tiobarbituric acid reactive substances between the deficient and adequate groups. These results indicate that short-term ascorbic acid deficiency does not impair antioxidant status in the lens of guinea pigs despite induction of severe ascorbic acid depletion in the tissue, which may result in no cataract formation.
关键词：antioxidants;lipid peroxidation;antioxidant status;ascorbic acid deficiency (guinea pig);lens