文章基本信息

标题：Teratogenic Effects of Triethylene Tetramine Dihydrochloride on the Mouse Brain
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作者：Harumi TANAKA ; Kenichirou INOMATA ; Masataka ARIMA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1993
卷号：39
期号：2
页码：177-188
DOI：10.3177/jnsv.39.177
出版社：Center for Academic Publications Japan
摘要：The teratogenic effects of triethylene tetramine dihydro-chloride (Trien-2HC1) on fetal mouse brain were studied on gestational day 19. Trien-2HC1 was given throughout pregnancy at levels of 0 (control), 3, 000, 6, 000, or 12, 000 mg/liter as drinking water, ad libitum. Mean litter size and live fetus per dam at birth were not significantly different among the four groups. The frequency of gross brain ab-normalities in live fetus at birth such as hemorrhages, delayed ossification in cranium, hydrocephaly, exencephaly, and microcephaly increased with increasing levels of the drug. Microscopically, dysorganization of neuro-nal cell layers, spongiform changes in white matter, and reduced myelin development were noted in the coronally sectioned cerebrum from Trien-2HC1-treated fetus. These abnormal findings increased dose-dependently in regard to the extent and severity at the levels of 6, 000 and 12, 000 mg/ liter. No such changes were observed in the cerebrum of controls. These results suggest that microscopic changes in fetal brain caused by Trien-2HC1 may be in part similar to those in brindled mutant mouse. Special attention should be paid to the developing fetal brain when Trien-2HC1 is used during pregnancy.
关键词：triethylene tetramine dihydrochloride;fetal mouse, brain abnormality, copper-chelating drug;teratogenicity;spongiform change;delayed ossification;exencephaly;Wilson's disease;pregnancy