文章基本信息

标题：Effect of a Glutamine-Supplemented Diet on Response to Methicillin-Resistant Staphylococcus aureus Infection in Mice
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作者：Isao SUZUKI ; Yoko MATSUMOTO ; Andrew A. ADJEI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1993
卷号：39
期号：4
页码：405-410
DOI：10.3177/jnsv.39.405
出版社：Center for Academic Publications Japan
摘要：The following study was undertaken to determine whether dietary supplementation with glutamine can be used to modulate the immune response following challenge with methicillin-resistant Staphylococcus aureus (MRSA) organisms in mice. Thirty BALB/c female mice were randomized into 3 groups: group A ( n =10) were fed 20% casein diet (control), whereas the mice in Groups B ( n =10) and C ( n =10) were given 20% casein diet supplemented with 2 and 4% glutamine, respectively. The diets were made isonitrogenous by glycine and alanine supplementation. On the 10th day on these treatments, each mouse was challenged intravenously with 2×10⁸ colony-forming units (CFU)/ml of MRSA organisms and mortality was noted for 20 days. The survival rate in Group A (20%) tended to be lower than the rates in Group B (40%), and Group C (70%). CFU values of spleen and kidney of the surviving mice 20 days post challenge were not different among the three groups ( p <0.05). The present results suggest that dietary glutamine supplementation may be effective as a nutritional immunomodulator for the recovery from MRSA infection.
关键词：MRSA;glutamine;infection;mouse