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标题：Cyanidin 3-O-β-D-Glucoside Attenuates the Hepatic Ischemia-Reperfusion Injury through a Decrease in the Neutrophil Chemoattractant Production in Rats
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作者：Takanori TSUDA ; Fumihiko HORIO ; Yoji KATO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2002
卷号：48
期号：2
页码：134-141
DOI：10.3177/jnsv.48.134
出版社：Center for Academic Publications Japan
摘要：We have shown that the orally administered cyanidin 3- O -β-D-glucoside (C3G) attenuates the hepatic ischemia-reperfusion (I/R) injury, which was used as a model for oxidative stress through a decrease in neutrophil chemoattractant production in rats. The rats were subjected to hepatic I/R at 30 min after the administration of C3G (0.9 mmol/kg body weight) or vehicle. I/R treatment resulted in the elevation of oxidative stress marker [liver thiobarbituric acid-reactive substance, N^ε-(hexanonyl) lysine and dity-rosine] levels in the liver and of the serum activities of marker enzymes for liver injury. The administration of C3G significantly suppressed these elevations, which had been caused by hepatic I/R. Liver myeloperoxidase activity, a useful marker for neutrophil infiltration into tissues, and the plasma and liver concentration of cytokine-induced neutrophil chemoattractant-1(CINC-1), which has a potent chemotactic activity, were markedly elevated in the control group after hepatic I/R. However, these elevations were significantly suppressed in the C3G group. C3G and its metabolites in the plasma and liver were detected in the C3G group after hepatic I/R. These results suggest that the absorbed C3G and/or its metabolites can act as antioxidants in the blood and liver and scavenge the reactive oxygen species, and brought on a decrease in neutrophil infiltration into the liver through the suppression of CINC-1 production and the tissue damage caused by neutrophils after I/R is attenuated.
关键词：anthocyanin;cyanidin 3-O-β-D-glucoside;antioxidant;ischemia-reperfusion injury;cytokine-induced neutrophil chemoattractant