文章基本信息

标题：Cyanidin 3-O-β-D-glucoside Suppresses Nitric Oxide Production during a Zymosan Treatment in Rats
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作者：Takanori TSUDA ; Fumihiko HORIO ; Toshihiko OSAWA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2002
卷号：48
期号：4
页码：305-310
DOI：10.3177/jnsv.48.305
出版社：Center for Academic Publications Japan
摘要：Anthocyanins are used for food color, and they are widely distributed in the human diets, suggesting that we ingest considerable amounts of anthocyanins from plant-based daily diets. We have demonstrated that a typical anthocyanin, cyanidin 3- O -β-D-glucoside (C3G), suppressed the zymosan-induced inflammatory response in rats when it was orally administered. The elevation of the peritoneal exudate NO_X, tumor necrosis factor (TNF) α interleukin-1β (IL-1β), IL-6, and the cytokine-induced neutrophil chemoattrac-tant-1(CINC-1) concentrations were significantly suppressed by the administration of C3G. The zymosan treatment resulted in an increase in the serum a₂-macroglobulin and decreases in the serum albumin and transferrin levels, which are recognized as acute phase proteins. However, these levels were normalized by the administration of C3G. The inducible nitric oxide synthase (iNOS) protein level in the peritoneal exudate cells was markedly elevated in the control group treated with zymosan. However, the administration of C3G significantly reduced the level of iNOS in the peritoneal exudate cells. Taken altogether, our findings provide a biochemical basis for the use of C3G as a functional food factor and can also have important implications for the prevention of the NO-mediated inflammatory diseases.
关键词：anthocyanin;cyanidin 3-O-β-D-glucoside;inflammation;nitric oxide;inducible nitric oxide synthase