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标题：Polyunsaturated Fatty Acid (PUFA) Changes in Serum and Liver of Undernourished Rats Given Dietary Vitamin B6 Supplementation
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作者：Jerzy BERTRANDT ; Anna KLOS ; Bogdan DEBSKI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2005
卷号：51
期号：3
页码：129-134
DOI：10.3177/jnsv.51.129
出版社：Center for Academic Publications Japan
摘要：The influence of vitamin B₆ on linoleic (LA), α-linolenic (ALA), arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid content in serum and liver of rats fed with protein-energy deficient diets for 90d, was studied. To estimate the effect of dietary supplementation with vitamin B₆ on the composition and level of fatty acids in the serum and liver of rats, two experiments were performed. In these experiments control rats were fed ad libitum semisynthetic isocaloric diets of 1, 466.5 kJ/100g (350kcal/100g) throughout 90d while the examined rats were offered 50% and 30% of the previously determined daily intake of the diet consumed in the control group. The experimental diet was supplemented with vitamin B₆ to the level 4-times higher than in the control diet. A reduction to the half consumption of a standard diet supplemented with vitamin B₆ caused a significant decrease of LA and ALA in blood serum at 30 and 60d. At 90d of the experi-ment the value of LA was lower and the content of AA was higher in comparison to the con-trol group. After 30d of consumption of vitamin B₆ enriched diet in rats subjected to feed restriction to only 30% of the control intake, an increase of ALA and a decrease of AA, EPA and DHA were noticed in serum. At 60d an increase of DHA was observed. Ninety days of feeding this diet caused a significant increase of AA level. Feeding animals for 90d with a vitamin B₆ enriched diet, with limited consumption to 50%, caused a significant increase of ALA content in liver. Further limitation of this diet consumption to 30% caused a significant decrease of LA and ALA and an increase of EPA content.
关键词：polyunsaturated fatty acids;vitamin B6;protein-energy malnutrition