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标题：Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds
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作者：Takako NAKAGAWA ; Takako YOKOZAWA ; Akiko SATOH 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2005
卷号：51
期号：4
页码：283-286
DOI：10.3177/jnsv.51.283
出版社：Center for Academic Publications Japan
摘要：The effects of proanthocyanidin-rich extract in rats subjected to renal Ischemia-reperfusion were examined. Proanthocyanidin-rich extract, which is prepared from grape seeds ( Vitis vinifera L.), was given orally at doses of 5 and 10mg/kg body weight/ d for 20 consecutive days prior to Ischemia-reperfusion. Administration of proanthocyanU din-rich extract attenuated renal dysfunction, as indicated by serum urea nitrogen and creatinine levels. Additionally, in the ischemic-reperfused kidneys, increased levels of thiobarbituric acid (TBA)-reactive substance and alterations of antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase (GSH-Px) were observed. Proanthocyanidin-rich extract-treated groups showed significantly reduced renal TBA-reactive substance levels and enhanced catalase and GSH-Px activities, These results suggest that proanthocyanidin-rich extract has protective effects against Ischemia reperfusion-induced renal damage associated with oxidative stress.
关键词：proanthocyanidin-rich extract;Ischemia-reperfusion;thiobarbituric acidreactive substance;catalase;glutathione peroxidase