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标题：Effect of Intermittent Supplementation with Selenate on Selenium Status of Rats Fed Selenium-Deficient Diet
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作者：Satoru SUGIHARA ; Kenji FUKUNAGA ; Toshimasa NISHIYAMA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2005
卷号：51
期号：6
页码：478-481
DOI：10.3177/jnsv.51.478
出版社：Center for Academic Publications Japan
摘要：To examine the selenium (Se) status of rats intermittently supplemented with Se, we measured tissue Se contents and glutathione peroxidase (GPx) activities in rats fed a Se-deficient diet intermittently supplemented with selenate. In experiment 1, four groups of male 4-wk-old Wistar rats were fed a Torula yeast-based Se-deficient diet (Se content, <0.01μg/g) for 2 8 d. During the experimental period, the diet of each group was supplemented with sodium selenate (0.17μg Se/g) for 0, 1, 2 or 7 d/wk. The tissue Se contents and GPx activities both increased gradually with an increase in frequency of the selenate supplementation, and significant linear regressions were observed between the frequency and these Se indices. In particular, the correlation coefficient in the liver and plasma indices was nearly equal to a value of 1.0. In experiment 2, three groups of rats were fed the Se-deficient basal diet for 2 8 d. Among these, one group was daily supplemented with sodium selenate to the Se-deficient diet at a level of 0.17μg Se/g, and another group was intermittently supplemented with the selenate at a level of 1.19μg Se/g for 1 d/wk. The tissue Se contents and GPx activities both were increased by the selenate supplementation and no significant difference was observed between daily and weekly supplementation in the Se indices except in erythrocyte Se. These results indicate that Se status in the growth period is dependent on total Se intake in this period and that weekly intermittent supplementation with Se can maintain adequate Se status.
关键词：selenium;selenium status;selenate;intermittent supplementation;glutathione peroxidase