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标题：CURATIVE EFFECTS OF 1α-HYDROXYCHOLECALCI-FEROL ON CALCIUM METABOLISM AND BONE DISEASE IN PATIENTS WITH CHRONIC RENAL FAILURE
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作者：Minoru HIROOKA ; Hiroshi WAKO ; Chikara KANEKO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1975
卷号：21
期号：4
页码：277-285
DOI：10.3177/jnsv.21.277
出版社：Center for Academic Publications Japan
摘要：Synthetic 1α-hydroxycholecalciferol (lα-OH-D₃) was given intravenously in a dose of 2.5-10μg per day to three patients with chronic renal failure. As little as 10μg of lα-OH-D₃ daily for a week improved intestinal calcium absorption to a normal level, raised serum calcium, and reduced serum alkaline phosphatase. Severe rickets which had not responded to large amounts (>200mg in total) of vitamin D₂ was markedly cured with 2.5μg of lα-OH-D₃ given daily for 3 weeks. These clinical data hold promise that lα-OH-D₃ is certainly useful in the improvement of intestinal malabsorption of calcium and bone diseases in renal failure.