文章基本信息

标题：IDENTIFICATION OF THE CHEMICAL STRUCTURES OF SCHIZOFLAVINS AS 7, 8-DIMETHYL-10-(2, 3, 4- TRIHYDROXY-4-FORMYLBUTYL) ISOALLOXAZINE AND 7, 8-DIMETHYL-10-(2, 3, 4-TRIHYDROXY-4-CARBOXYBUTYL) ISOALLOXAZINE
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作者：Sei TACHIBANA ; Toshio MURAKAMI ; Toshikazu NINOMIYA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1975
卷号：21
期号：5
页码：347-353
DOI：10.3177/jnsv.21.347
出版社：Center for Academic Publications Japan
摘要：Studies to elucidate the chemical structures of new flavins formed by Schizophyllum commune , namely schizoflavin (SF), were carried out. It was found by an enzymatic study that riboflavin (FR) was apparently converted via SF₂ to SF₁, and that SF₂ was a direct precursor of SF₁. SF₁ was crystallized from water and repeated recrystallization produced yellow needles. The carboxylic group in SF₁ and the aldehyde group in SF₂ were detected by spot tests. Elemental analyses and the spectroscopic analyses of the crystalline SF₁ supported the existence of carboxylic group in the terminal of its ribityl moiety. From these experimental results, schizoflavins were revealed to be oxidation products of FR that C-5' site of its ribityl moiety is oxidized. Consequently, SF₁ and SF₂ were identified as 7, 8-dimethyl-10-(2, 3, 4-trihydroxy-4-carboxybutyl) isoalloxazine and 7, 8-dimethyl-10-(2, 3, 4-trihydroxy-4-formylbutyl) isoal-loxazine, respectively.