文章基本信息

标题：Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation
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作者：Qunwei ZHANG ; Yukinori KUSAKA ; Kazuhiro SATO 等
期刊名称：Journal of Occupational Health
印刷版ISSN：1341-9145
电子版ISSN：1348-9585
出版年度：1998
卷号：40
期号：3
页码：171-176
DOI：10.1539/joh.40.171
出版社：Japan Society for Occupational Health
摘要：Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation: Qunwei ZHANG, et al. Department of Environment Health. Fukui Medical University -To study the lung acute and subacute toxicity of ultrafine nickel particles, rats were intratracheally instilled with 0, 0.1, 0.5, 1 and 5 mg ultrafine nickel (Uf-Ni), respectively. At 3 days after injection, the body weight and wet lung weight were determined. At the same time, bronchoalveolar lavage fluid (BALF) was analyzed for lactate dehydrogenase (LDH), total protein (TP), and total cell and differential cell counts. The results showed that indicators of lung injury and inflammation in BALF were markedly raised with increased Uf-Ni from 0 to 1 mg, and there were no differences in the indices between injection of Uf-Ni at 1 mg and at 5 mg. Rats were intratracheally instilled with 1 mg Uf-Ni, and wet lung weight, and bronchoalveolar lavage fluid (BALF) profiles were analyzed 1, 3, 7, 15 and 30 days later. The effects of Uf-Ni on indices that can be presumed to reflect epithelial injury and permeability (LDH or TP) were dramatically increased from day I up to 30 days after injection. Lung histology findings generally confirmed the BALF data, showing severe lung inflammation at I day after injection of Uf-Ni, and epithelial hyperplasia and inflammation still present at 30 days after injection. Our findings suggest that Uf-Ni causes persistent inflammation following instillation of a small dose.
关键词：Ultrafine nickel;Bronchoalveolar lavage;Lung toxicity