文章基本信息

标题：EFFECT OF α-TOCOPHEROL ON THE BINDING OF BENZO(A)PYRENE TO NUCLEAR MACROMOLECULES
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作者：Takao MATSUURA ; Hisao UEYAMA ; Shimpachiro NOMI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1979
卷号：25
期号：6
页码：495-504
DOI：10.3177/jnsv.25.495
出版社：Center for Academic Publications Japan
摘要：The binding of metabolically activated ¹⁴C-benzo(a)pyrene (BP) to rat liver nuclei was studied. The nuclear framework structure, termed the nuclear matrix, was found to bind BP preferably. α-Tocopherol inhibited the binding of BP to nuclear macromolecules in the presence of phenobarbital (PB)-induced microsomes. α-Tocopherol decreased the level of BP metabolites in nuclei, though it did not inhibit the activation of BP by PB-induced microsomes.
关键词：tocopherol;antioxidant;benzo(a)pyrene;carcinogen;nuclei;nuclear matrix;nuclear macromolecules;high-pressure liquid chroma-tography