文章基本信息

标题：EFFECT OF L-ASCORBATE 2-SULFATE ON FATTY LIVER AND HYPERLIPIDEMIA INDUCED BY VARIOUS TREATMENTS IN RATS AND GUINEA PIGS
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作者：Mamoru TERADA ; Shinya WAKUSAWA ; Yoshinori WATANABE 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1980
卷号：26
期号：6
页码：521-534
DOI：10.3177/jnsv.26.521
出版社：Center for Academic Publications Japan
摘要：Effects of L-ascorbate 2-sulfate (AAS) on fatty liver and hyperlipidemia induced by various treatments were studied in rats and guinea pigs. L-Ascorbic acid (AA) (50 or 175mg/kg), a reference compound, lowered the lipid levels in the serum and/or liver in guinea pigs, while AA had little effect in rats. On the other hand, AAS (300mg/kg) was effective in both animals. In rats, AAS lowered cholesterol and triglycerides in the serum from ethionine-treated animals and in the liver from orotic acid-supplemented animals. In guinea pigs, this compound lowered cholesterol and triglycerides in the serum from ethionine-treated animals, lipids in the liver from cholesterolsupplemented animals, and lipids in the serum and liver from scorbutic animals. AA markedly increased the content of AA in the organs in all experiments, while AAS had a slight effect. Thus, it is suggested that AAS exerts its hypolipidemic and lipotropic effects by the specific actions of AAS.
关键词：L-ascorbate 2-sulfate;fatty liver;hyperlipidemia;rat;guinea pig