文章基本信息

标题：Effect of Vitamin A Compounds on the Covalent Binding of Benzo (a) pyrene to Nuclear Macromolecules
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作者：Shinhachiro NOMI ; Takao MATSUURA ; Hisao UEYAMA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1981
卷号：27
期号：1
页码：33-41
DOI：10.3177/jnsv.27.33
出版社：Center for Academic Publications Japan
摘要：Effect of vitamin A compounds on the covalent binding of benzo (a) pyrene [B (a) P] to subnuclear components was studied using rat liver nuclei in vitro. The retinol-induced inhibition of the covalent binding of B (a) P depended both on the dose and the time of addition. Retinal and retinyl acetate were both potent inhibitors, but retinoic acid was less effective. Retinol induced marked inhibition of B (a) P binding to DNA and protein of the nuclear matrix but had little or no effect on the labeling of bulk DNA and protein in chromatin fractions.
关键词：benzo (a) pyrene;covalent binding;nuclear macromolecules;nuclear matrix;retinol;retinal;retinoic acid;retinyl acetate