文章基本信息

标题：Stability, Bactericidal Activity, Vitamin B6 Activity and Gastrointestinal Absorption of Benzoic Acid Esters of Pyridoxine
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作者：Nobuyasu MIZUNO ; Miyako FUKUMOTO-HATO ; Miyuki MATSUMOTO-YOSHINO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1981
卷号：27
期号：3
页码：165-175
DOI：10.3177/jnsv.27.165
出版社：Center for Academic Publications Japan
摘要：α⁴- O -Benzoyl-pyridoxine (PN-4'MB) and α⁵- O -benzoyl-pyridoxine (PN-5'MB) were hydrolyzed in 10% aqueous solution of acetone at pH 1-4. They were hydrolyzed obeying apparent first-order kinetics. In the pH range of 1-7, PN-4'MB was hydrolyzed 10 times faster than PN-5'MB. At pH 7-12, an interconversion between the two derivatives was observed. They were bactericidal against Escherichia coli and Bacillus subtilis and prevented severe convulsions induced in mouse by 4'-methoxypyridoxine, a potent antagonist of vitamin B₆. PN-4'MB was hydrolyzed with the homogenate of rat liver more easily than PN-5'MB. The metabolite of PN-MBs in man was identified as 4'-pyridoxic acid, i.e. , a principal metabolite of PN, using high-performance liquid chromatography. The amount of urinary excretion of 4'-pyridoxic acid in 10 hr after oral administration of PN-4'MB or PN-5'MB was as large as that of PN.
关键词：α4-O-benzoyl-pyridoxine;α5-O-benzoyl-pyridoxine;stability;bactericidal activity;vitamin B6 activity;gastrointestinal absorption;4'-pyridoxic acid;Escherichia coli;Bacillus subtilis