文章基本信息

标题：Effects of β-Sitosterol on the Concentrations of Serum and Liver Cholesterol and Serum Apolipoproteins in Rats Fed Butter Fat
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作者：Michihiro SUGANO ; Ikuo IKEDA ; Katsumi IMAIZUMI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1982
卷号：28
期号：2
页码：117-126
DOI：10.3177/jnsv.28.117
出版社：Center for Academic Publications Japan
摘要：Male rats were fed on semipurified cholesterol-free diets containing butter fat with or without supplementary β-sitosterol. The expected rise of serum cholesterol caused by butter fat, as compared with safflower oil, was not able to be demonstrated, and hence the hypo-cholesterolemic effect of β-sitosterol as well. However, the plant sterol effectively lowered the liver cholesterol level. Similar responses were also observed in mice. The distribution of cholesterol in serum lipoproteins remained unchanged among different dietary regimens. Butter fat in-creased the concentration of serum apoA-I in relation to safflower oil. There was possibly a trend toward higher serum apoA-I with sup-plementation of β-sitosterol in a butter-fat diet. The effect of the plant sterol on serum apoB was rather variable. The observation strongly suggests that alteration in cholesterol metabolism in these rodents may not satisfactorily be estimated by the serum cholesterol parameter alone when diets free of cholesterol are fed. The concentration of hepatic cholesterol and serum apolipoproteins seems a more apposite measure for this purpose.
关键词：β-sitosterol;butter fat;serum and liver cholesterol;serum apolipoproteins