文章基本信息

标题：Effects of High-Fructose Diet on Lipogenic Enzymes and Their Substrate and Effector Levels in Diabetic Rats
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作者：Hitomi FUKUDA ; Nobuko IRITANI ; Takehiko TANAKA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1983
卷号：29
期号：6
页码：691-699
DOI：10.3177/jnsv.29.691
出版社：Center for Academic Publications Japan
摘要：When rats adapted to a stock diet were fed on various highcarbohydrate diets, the hepatic activities of glucose-6-phosphate dehydrogenase, malic enzyme and acetyl-CoA carboxylase were more greatly increased by fructose than by any other carbohydrate. Even in the diabetic state, the enzyme activities were somewhat increased by fructose feeding. After feeding on the diets for 9 days, the hepatic concentrations of intermediates of carbohydrate metabolism were generally lower in the diabetics than in the normals. Moreover, in both the normal and diabetic rats, the concentrations of fructose 1-phosphate, acetyl-CoA, citrate and malate were increased by fructose as were the enzyme activities. These results suggest that the metabolic pathway of fructose is predominant with respect to that of glucose and consequently lipogenesis may be able to be increased in the fructose-fed rats.
关键词：dietary carbohydrates;fructose;hepatic Lipogenic enzymes;intermediates of carbohydrate metabolism;diabetic rat