文章基本信息

标题：The Distribution of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in the Small Intestine of Rats Fed Raw or Gelatinized Starch as a Carbohydrate Source
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作者：Hirosuke OKU ; Takashi IDE ; Michihiro SUGANO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1984
卷号：30
期号：2
页码：171-178
DOI：10.3177/jnsv.30.171
出版社：Center for Academic Publications Japan
摘要：The effect of gelatinization of dietary starch (wheat, corn and potato) on the distribution of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase along the small intestine of rats was studied in villus and crypt cell populations isolated by graduated scraping. Gelatinized starch preferentially stimulated jejunal reductase activity in both villus and crypt cells and consequently retained the ileojejunal gradient for the reductase activity which is characteristic for rats fed on a sucrose or glucose-enriched semi-purified diet. The distribution of the reductase in rats fed the raw starches, however, depended on the degree of gelatinization of the preparations; raw wheat starch maintained the ileojejunal gradient, whereas the corn or potato starch eliminated the gradient, and with the latter in particular, the reductase activity tended to be higher in the ileum than in the jejunum. The digestibility of dietary starches seems to be closely related to the intertissue distribution of the intestinal HMG-CoA reductase activity.
关键词：small intestine;cholesterogenesis;HMG-CoA reductase;dietary starch;gelatinization;digestibility