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标题：Digestion and Absorption of Sugars and Sugar Substitutes in Rat Small Intestine
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作者：Yoshimitsu TSUJI ; Kazuhiko YAMADA ; Norimasa HOSOYA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1986
卷号：32
期号：1
页码：93-100
DOI：10.3177/jnsv.32.93
出版社：Center for Academic Publications Japan
摘要：The bioavailability of newly developed sugar substitutes was observed by measuring the transmural potential difference (APD) evoked by Na⁺ -dependent active trasport of glucose, which is supposed to be produced by the hydrolysis of sugar substitutes. Δ PD was measured using everted intestinal sac prepared from jejunum of adult rats and compared with the digestibility of sugar substitutes in the mucosal homogenate of everted sac. Δ PDs evoked by glucose, maltose or maltosylfructose had almost the same levels, however, the Δ PD evoked by sucrose was a little lower. Δ PDs evoked by maltitol or palatinose were low, and Δ PDs evoked by fructo-oligosaccharides were negligible. The hydrolyzing activities of these sugars and sugar substitutes by the mucosal homogenate were correlated with the Δ PDs. A significant positive correlation was observed between Δ PD_max of various sugars and sugar substitutes and the V _max of their corresponding hydrolyzing activities. Also, a significant positive cor-relation was observed between K_t and K_m values of these sugars. These results suggest that the absorption of sugar substitutes is dependent on digestibility by membrane digestive enzymes.
关键词：sugar substitutes;disaccharidase activity;transmural poten-tial difference;small intestine