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标题：Effect of Long-Term Supplementation of Folate on Folate Status in Plasma and Erythrocytes
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作者：Helmut HESEKER ; Gerhard SCHMITT
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1987
卷号：33
期号：3
页码：163-168
DOI：10.3177/jnsv.33.163
出版社：Center for Academic Publications Japan
摘要：Folate nutritional status was estimated by radioassay of folate levels in plasma and erythrocytes during and after aa long-term supplementation of folic acid. A 1-mg dose of folic acid per day was administered orally to 6 healthy subjects for 17 weeks. After 4 weeks of supplementation the mean folate concentration in plasma reached 11 ng/ml and remained constant thereafter, but decreased exponentially after stopping the supplementation. However, the folate concentrations in reticulocytes and erythrocytes increased linearly in all subjects during the supplementation. These results suggest that folate-rich, young erythrocytes are mixed at a constant rate with circulating ripe ones, which have a lower folate content, during folate supplementation.
关键词：folate;supplementation;plasma;erythrocyte;human;phy-siological doses;megadoses