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标题：Effects of Restricted Diet on Protein Metabolism Measured by [15N] Glycine in High-Fat-Diet-Induced Obese Rats
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作者：Yuriko OI ; Toyoko OKUDA ; Hiroko MIYOSHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1987
卷号：33
期号：4
页码：255-262
DOI：10.3177/jnsv.33.255
出版社：Center for Academic Publications Japan
摘要：The effect of restricted diets on protein metabolism was studied in obese rats (obesity had been induced by ad libitum feeding of a diet containing 30% fat and 25% casein). The obese rats were fed on one of three restricted diets, each containing 5% fat, for 2 weeks (restricted feeding groups); a high-protein diet (HPD, 50% casein), a standard-protein diet (SPD, 25% casein), or a low-protein diet (LPD, 5% casein). The food intake was restricted to 5g per day per rat. On the eleventh day, the rats were given [¹⁵N] glycine orally, and 4 days later, they were killed. The restricted feeding groups all showed similar weight losses (about 100g), 2 weeks after the start of the restricted diet. The ¹⁵N distribution in whole body was measured and results were compared with those of control rats given 5% or 30% fat diet ad libitum. The whole-body distribution of ¹⁵N in the HPD group was similar to that in the rats fed ad libitum although the diet intake was restricted. The results suggested that the amount of protein in a restricted diet is important for maintenance of protein metabolism in obese rats.
关键词：obese rat;protein metabolism;[15N] glycine;15N distribution;restricted feeding;ad libitum feeding;15N excretion;15N retention