文章基本信息

标题：Effects of Various Combinations of ω3 and ω6 Polyunsaturated Fats with Saturated Fat on Serum Lipid Levels and Eicosanoid Production in Rats
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作者：Joon Ho LEE ; Michihiro SUGANO ; Takashi IDE 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1988
卷号：34
期号：1
页码：117-129
DOI：10.3177/jnsv.34.117
出版社：Center for Academic Publications Japan
摘要：The effects of varying the ratio of polyunsaturated/saturated fatty acids (P/S) and ω3/ω6 polyunsaturated fatty acids (PUFA) of dietary fats on lipid metabolism were studied in rats using safflower oil (SF0), linseed oil (LSO), palm oil (PLO), and a 1:1 com-bination of these oils. The hypocholesterolemic and hypotriglyceride-mic effects depended on the P/S ratio of dietary fats, LSO (ω3 PUFA) being more effective than SFO (ω6 PUFA). A similar pattern of the response was observed on liver cholesterol and triglyceride. The liver cholesterol-lowering effect of LSO, but not SFO, remained even when they were combined with PLO. The activity of liver Δ⁶-desaturase tended to be higher while that of liver phospholipase A₂ was significantly lower in the LSO group than in the SFO or PLO groups. The aortic PGI₂ production and the production by platelets of thromboxane A₂ were significantly low in rats fed LSO accompanying a distinct reduction of arachidonate in tissue phospholipids. The depressing effect of LSO disappeared when it was combined with SFO but not with PLO. There were no significant differences in enzyme activities and eicosanoid production between SFO and PLO in spite of a large difference in their P/S ratio. Thus, lipid parameters examined were complicatedly regulated by the ratios of ω3/ω6 as well as P/S, suggesting an existence of an appropriate ratio for these variables.
关键词：P/S ratio;polyunsaturated fatty acid;Δ6-desaturase;phos-pholipase A2;thromboxane A2;prostacyclin (PGI2)