文章基本信息

标题：Changes in Glucose Uptake by and Phlorizin Binding to Brush-Border Membrane Vesicles of Small Intestine from Streptozotocin-Induced Diabetic Rats
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作者：Yoshimitsu TSUJI ; Kazuhiko YAMADA ; Norimasa HOSOYA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1988
卷号：34
期号：3
页码：327-334
DOI：10.3177/jnsv.34.327
出版社：Center for Academic Publications Japan
摘要：The changes in the intestinal glucose transport in strep-tozotocin-induced diabetic rats have been demonstrated with brush-border membrane vesicles. When Na⁺ -dependent D-glucose uptake and phlorizin binding activities were compared, both significantly increased either in the jejunum or ileum of diabetic rats compared with those of control. Kinetic studies showed the increases in the V _max of glucose transport and the maximum binding of phlorizin ( B _max), whereas the K _t. and K _d remained unchanged, respectively. These results suggested that the increase in glucose transport in diabetic rat intestine was due to the increase in the number of the intact glucose transporters.
关键词：streptozotocin-induced diabetes;brush-border membrane vesicles;glucose uptake;phlorizin binding