文章基本信息

标题：Inhibitory Effect of Acyclic Retinoid (Polyprenoic Acid) on the Secretion of α-Fetoprotein in CCl4-Treated Rats
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作者：Masataka OKUNO ; Yasutoshi MUTO ; Michimasa KATO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1990
卷号：36
期号：5
页码：437-446
DOI：10.3177/jnsv.36.437
出版社：Center for Academic Publications Japan
摘要：A study was conducted to examine the inhibitory effect of acyclic retinoid (polyprenoic acid) on the secretion of α-fetoprotein (AFP) in rats with chronic liver damage induced by CCl₄. Oral ad-ministration of the compound brought about a significant reduction of serum AFP levels at the time when liver cirrhosis was formed. Acyclic retinoid also decreased the activities of serum aminotransferases and ornithine carbamyl transferase, while it increased serum albumin levels, demonstrating the reduction of hepatic parenchymal damage. Significant negative correlation was observed between serum AFP and albumin levels. This cytoprotective effect of the retinoid on the parenchymal cell may well be related to the inhibition of the synthesis and/or secretion of AFP. No significant side effect was observed, despite a long-term ad-ministration of the compound. The present finding will provide a po-tential scope for the future use of acyclic retinoid for the treatment of chronic liver damage.
关键词：acyclic retinoid;α-fetoprotein;cytoprotection;carbon tetrachloride;cancer chemoprevention;transcriptional switch