文章基本信息

标题：Effects of Early Thiamin Deficiency and Subsequent Rehabilitation on the Cholinergic System in Developing Rat Brain
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作者：A. B. KULKARNI ; B. B. GAITONDE
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1983
卷号：29
期号：2
页码：217-225
DOI：10.3177/jnsv.29.217
出版社：Center for Academic Publications Japan
摘要：1. The effects of thiamin deficiency during pregnancy and/or lactation on brain cholinergic system in rat pups were studied. Dietary rehabilitation for a period of 5 weeks from the 28th day was instituted to study possible ‘catch-up’ in the brain acetylcholine levels. 2. Brain acetylcholine level was found to be significantly decreased on the 21st and 28th days in pups of the dams fed thiamin deficient diet during gestation and lactation, whereas it was decreased on the 28th day in pups of the dams fed thiamin deficient diet during lactation. Activities of Cholinergic enzymes remained unaltered in both the deficient groups. 3. Subsequent dietary rehabilitation was found to reverse the deficits in brain acetylcholine levels.
关键词：thiamin deficiency;acetylcholine;acetylcholine esterase;choline acetylase