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标题：Effects of Protein and Energy on Dietary Selection and Protein Utilization in Rats with Ventromedial Hypothalamic Lesions
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作者：Fujiko SHIZUKA ; Kyoichi KISHI ; Goro INOUEI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1983
卷号：29
期号：2
页码：187-199
DOI：10.3177/jnsv.29.187
出版社：Center for Academic Publications Japan
摘要：The effect of bilateral destruction of the ventromedial hypothalamus (VMH) on protein and energy intakes was examined in relation to protein utilization. In Experiment 1, rats with VMH lesions were allowed to select protein (either casein or wheat gluten) and energy from two diets containing 70% and 5% protein, respectively. In Experiment 2, they were restricted to 0, 100 and 200mg N/day of protein and given free access to protein-free diet. In Experiment 3, they were restricted to 2 and 5g/day of protein-free diet but given 92% protein diet ad libitum . Self-selecting rats with VMH lesions consumed about 100kcal/day regardless of the protein source, in contrast to sham-operated controls which consumed 75kcal/day. They showed increased non-protein energy intake with constant protein consumption resulting in normal protein retention with increased body fat. When protein intake was restricted to 200mg N/ day, energy intake was reduced in animals given diet containing wheat gluten more than in those given diet containing casein, resulting in lower protein utilization. Therefore, food intake depended upon the amount of dietary protein. Rats with VMH lesions showed an exaggerated response to the ratio of protein to energy in the diet and consumed more energy from balanced diet but showed more reduction in food intake than controls in response to diet with an inappropriate ratio of protein to energy. The present study confirmed that the VMH was related to regulation of energy intake but not protein intake. It is suggested that protein intake is regulated in relation to maintenance of body protein in rats with VMH lesions as well as in normal rats.
关键词：self-selection;protein restriction;energy restriction;protein utilization;protein intake regulation;VMH lesion