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标题：Decreased Responsiveness of Pituitary-Adrenal Axis to Stress in Vitamin A-Depleted Rats
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作者：Kiwao NAKANO ; Reiko MIZUTANI
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1983
卷号：29
期号：3
页码：353-363
DOI：10.3177/jnsv.29.353
出版社：Center for Academic Publications Japan
摘要：The functional ability of pituitary-adrenocortical system in relation to adequacy of vitamin A-nutriture was studied by comparing magnitude of its response to stress in vitamin A-depleted rats with that in normal animals. Repeated 4 h-daily immobilizations provoked a significant increase in urinary excretion of free plus conjugated transcortinbindable corticosteroids with a concomitant rise in serum and adrenal content of free corticosteroids. In the vitamin A-depleted rats stress-evoked increase in urinary excretion and, serum and adrenal level of corticosteroids was less marked than those in the normal animals. The serum ACTH response to the stress was also decreased in the vitamin Adepleted rats. These results suggest that stress-induced activation of the pituitary-adrenocortical axis is significantly reduced in the vitamin Adepleted rats and that this depression is due, in part, to reduction of hypophyseal secretion of ACTH.
关键词：immobilization stress;urinary corticosteroids;vitamin Adepletion