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标题：The Effect of 1, 25-Dihydroxycholecalciferol on the Changes of Bone γ-Carboxyglutamic Acid-Containing Protein in Bone and Serum of Developing Chick
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作者：Chiharu TSUTSUMI ; Norimasa HOSOYA ; Sachiko MORIUCHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1985
卷号：31
期号：1
页码：21-28
DOI：10.3177/jnsv.31.21
出版社：Center for Academic Publications Japan
摘要：The effects of 1, 25-dihydroxycholecalciferol(1, 25-(OH)₂-D₃) injection into developing chick embryos on bone γ-carboxyglutamic acid-containing protein (BGP) levels in bone and serum were observed in relation to those on calcium metabolism using chick embryos and chicks aged from 13 days' incubation to 7 days of age. Chick BGP was determined by radioimmunoassay using antiserum to purified chick BGP. The injection of 1, 25-(OH)₂-D₃ into the developing chick embryos of 13 days' incubation resulted in the increases of bone BGP levels at hatching and at 2 days of age. However, the distribution of bone BGP at hatching was not influenced by 1, 25-(OH)₂-D₃. On the other hand, serum BGP levels were significantly increased by 1, 25-(OH)₂-D₃ at 14, 15, 18 days' incubation and at 2 days of age. The early changes of serum BGP levels after 1, 25-(OH)₂-D₃ treatment were correlated with the increases of serum calcium concentrations and the decreases of inorganic phosphorus concentrations. These results suggest that 1, 25-(OH)₂-D₃ may directly or indirectly mediate BGP synthesis or secretion associated with calcium metabolism.
关键词：1,25-dihydroxycholecalciferol(1,25-(OH)2-D3);bone γ-car-boxyglutamic acid-containing protein (BGP);developing chick