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标题：Changes of Sugar-Evoked Transmural Potential Differences in Intestine of Rats with Streptozotocin-Induced Diabetes
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作者：Yoshimitsu TSUJI ; Kazuhiko YAMADA ; Norimasa HOSOYA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1985
卷号：31
期号：3
页码：317-326
DOI：10.3177/jnsv.31.317
出版社：Center for Academic Publications Japan
摘要：The changes of the transmural electrical potential difference ( Δ PD) evoked by infusion of glucose, maltose . and sucrose and the disaccharidase activities in the everted intestine were studied in diabetic rats. After the induction of diabetes by streptozotocin, Δ PDs evoked by sugars and the enzyme activities were observed in the jejunum and ileum. Δ PDs evoked by glucose, maltose and sucrose markedly increased both in the jejunum and ileum of diabetic rats. The Kt values for these sugars in diabetic rats were the same as those of control rats. The V _max values were significantly increased in the ileum of diabetic rats. Maltase and sucrase activities in the ileum increased in diabetic rats. Highly significant linear correlations were found between the Δ PDs evoked by glucose and the Δ PDs evoked by maltose or sucrose both in the jejunum and ileum of control and diabetic rats. However, Δ PDs evoked by maltose and sucrose did not correlate with maltase and sucrase activities in the jejunum. In the ileum, Δ PDs evoked by sucrose correlated with the sucrase activity which was very low. These results suggest that the increase of transport of glucose derived from disaccharides in the diabetes induced by streptozotocin is mainly due to the increased activity of the glucose transport system, but not due to the increase of disaccharidase activities.
关键词：transmural potential difference;streptozotocin-induced diabetes;disaccharidase activity;intestinal sugar absorption