文章基本信息

标题：Changes in the Concentrations of Vitamin D and Its Me tabolites in the Plasma of Healthy Subjects Orally Given Physiological Doses of Vitamin D2 by Multivitamin or Vitamin D Preparations
本地全文：下载
作者：Masayoshi MATSUOKA ; Hiroshi OTSUKA ; Sonoko MASUDA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1989
卷号：35
期号：4
页码：253-266
DOI：10.3177/jnsv.35.253
出版社：Center for Academic Publications Japan
摘要：Changes in the concentrations of vitamin D and its metabolites in plasma of healthy subjects orally given physiological doses of vitamin D₂ by multivitamin or vitamin D liquid preparations were determined and the bioavailability of vitamin D was studied. Separative assay on the D₂ and D₃ compounds of vitamin D, 25-hydroxyvitamin D (25-OH-D), 24R, 25-dihydroxyvitamin D [24, 25(OH)₂D], and 1 α, 25-dihydroxyvitamin D [1, 25(OH)₂D] was performed in plasma of eight healthy male volunteers. When the concentrations of vitamin D and its metabolites in plasma of volunteers were assayed after daily oral administration of 400 IU of vitamin D₂ in a form of multivitamin tablet for 1 week, the variations of vitamin D₃ and its metabolites in plasma levels were very small. In contrast, the concentrations of 25-OH-D₂ and 1, 25(OH)2D₂ slightly increased after the administration, while neither vitamin D₂ nor 24, 25(OH)₂D₂ was detected. A single dose of 4, 000 IU of vitamin D₂ was orally given to the volunteers in a form of a vitamin D liquid preparation and the hourly variations were observed during 24 h. These concentrations of vitamin D2, 25-OH-D₂, and 1, 25(OH)2D₂ were slightly higher than those of the repeated doses. The result suggests that even the high dose of 4, 000 IU has little effect on the plasma levels of vitamin D₂ and its metabolites by a single dose, indicating a low risk for hypervitaminosis D.
关键词：vitamin D;25-hydroxyvitamin D;24,25-dihydroxyvitamin D;1 α,25-dihydroxyvitamin D;bioavailability