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标题：Concentrations of Vitamin D-Binding Protein and Vitamin D Metabolites in Plasma of Patients with Liver Cirrhosis
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作者：Sonoko MASUDA ; Toshio OKANO ; Kiyoko OSAWA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1989
卷号：35
期号：4
页码：225-234
DOI：10.3177/jnsv.35.225
出版社：Center for Academic Publications Japan
摘要：Plasma levels of vitamin D-binding protein (DBP) and vitamin D metabolites in patients with decompensated and compensated liver cirrhosis were assayed. Plasma levels of DBP in the decompensated group were significantly lower than those in the compensated group, but both were lower than the normal range. The plasma levels of 25-hydroxyvitamin D (25-OH-D) and 1α, 25-dihydroxyvitamin D [1, 25 (OH)₂D] in the compensated group were within the respective normal ranges, whereas both values in the decompensated group were significantly lower than those in the compensated group. Most of 25-OH-D (higher than 96%) was confirmed to be circulated as a bound form with DBP in the plasma of not only the compensated but also the decompensated group. When vitamin D₂ was given to the decompensated group, a significant increase of 1, 25 (OH)₂D levels in the plasma could not be observed while 25-OH-D levels were increased. On the other hand, the administration of 1α-hydroxyvitamin D₃ (1α-OH-D₃) to the decompensated group caused a significant increase in the plasma levels of 1, 25 (OH)₂D. Therefore, we suggest that the administration of 1α-OH-D₃ is useful for the treatment of bone disease induced by liver cirrhosis.
关键词：vitamin D;vitamin D-binding protein;25-hydroxyvitamin D;1α, 25-dihydroxyvitamin D;liver cirrhosis