文章基本信息

标题：Correlation between Plasma α-Cysteine Proteinase Inhibitor Level and Pyruvate Kinase Activity in Vitamin E-Deficient Rats
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作者：Naoko HARADA ; Shin-ichi SAITO ; Kayoko MINAKATA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1992
卷号：38
期号：4
页码：397-404
DOI：10.3177/jnsv.38.397
出版社：Center for Academic Publications Japan
摘要：Weaning rats were divided into two groups, one group being fed a vitamin E-deficient diet, and the other an α-tocopherol-containing (50mg/kg) control diet. Rats were killed at 1, 2, 3 and 4 months of feeding. The following results were obtained. 1. Both plasma and liver α-tocopherol levels decreased greatly by feeding vitamin E-deficient diet for 1 month, and thereafter decreased gradually by continued feeding. 2. Somehow different results were obtained concerning liver perox-idation value by the method of analysis. In the case of chemilumines-cence, the value increased by vitamin E deficiency during the first 2 months, but thereafter, the value was almost unchanged. On the contra-ry, in the case of TBA-RS, the value increased gradually throughout the entire 4 months of feeding period. 3. Both plasma α-CPI level and pyruvate kinase activity increased by vitamin E deficiency, showing similar pattern of change with feeding period. Especially, marked increase of these values was observed in vitamin E-deficient rats fed for longer than 2 months, and differences from control groups were highly significant (in both cases, at 2 months, p <0.005, and at 3 and 4 months, p <0.001). And, in vitamin E-deficient group, including all the rats fed on test diet for 1 to 4 months, correlation between both values was very high, and was highly significant ( r =0.9060, p <0.001).
关键词：vitamin E;proteinase inhibitor;pyruvate kinase;lipid peroxide