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标题：Effect of Intraperitoneally Administered Nucleoside-Nucleotide on the Recovery from Methicillin-resistant Staphylococcus aureus Strain 8985N Infection in Mice
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作者：Andrew A. ADJEI ; Fusae TAKAMINE ; Hiroomi YOKOYAMA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1992
卷号：38
期号：2
页码：221-225
DOI：10.3177/jnsv.38.221
出版社：Center for Academic Publications Japan
摘要：The effect of intraperitoneally administered nucleoside-nucleotide on the recovery from methicillin-resistant Staphylococcus aureus ( MRSA ) strain 8985N infection was studied in mice. Mice fed nucleic acid-free 20% casein diet were administered intraperitoneally with a nucleoside-nucleotide mixture or with saline (control group) daily for 30 days. On the tenth day on this treatment, mice were challenged with the bacteria. The survival rates were 25% and 72% for the control and nucleoside-nucleotide groups, respectively. The recovery of the survived mice from the infection was confirmed by the increment of body weight and the reduction of the bacteria in the organs. The results show the effectiveness of the intraperitoneal administration of the nucleoside-nucleotide mixture for the recovery from the MRSA strain 8985N in-fection in mice.
关键词：nucleoside;nucleotide;MRSA;mouse